Buy Methylphenidate Powder (Ritalin)


Methylphenidate, sold under the trade name Ritalin among others, is a stimulant medication used to treat attention deficit hyperactivity disorder and narcolepsy. It is a first line medication for ADHD. It may be taken by mouth or applied to the skin. Different formulations have varying durations of effect. .
Molar mass233.31 g/mol
Bioavailability~30% (range: 11–52%)
Melting point74 °C (165 °F)
ExcretionUrine (90%)
Boiling point136 °C (277 °F)


Methylphenidate (also known as ConcertaMethylinRitalin, among others) is stimulant substance of the phenethylamine class. Methylphenidate is the parent compound of the substituted phenidates, a family of compounds that includes ethylphenidateisopropylphenidate, and others. It acts primarily by enhancing the activity of the neurotransmitters dopamine and norepinephrine in the brain.

Methylphenidate was first licensed by the U.S. Food and Drug Administration (FDA) in 1955 for treating what was then known as “hyperactivity.” Although it was prescribed to patients as early as 1960, it only became heavily prescribed in the 1990s when the diagnosis of ADHD itself became more widely accepted..

Methylphenidate is approved for treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy. It is often used by students with or without ADHD to enhance their mental abilities, improve their concentration, and help them study.


Methylphenidate is a synthetic molecule of the substituted phenethylamine class. It contains a phenethylamine core featuring a phenyl ring bound to an amino (-NH2) group through an ethyl chain. It is structurally similar to amphetamine, featuring a substitution at Rα which is incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. Additionally, it contains a methyl acetate bound to R2 or its structure.

Methylphenidate is a chiral compound, presumably produced as a racemic mixture. It has an enantiopure also sold as a pharmaceutical; the dextrorotary enantiopure is known as “dexmethylphenidate” and is commonly sold as Focalin and Focalin XR.


Methylphenidate primarily acts as a dopaminenorepinephrine reuptake inhibitor. It is most active at modulating levels of dopamine and, to a lesser extent, norepinephrine.. Methylphenidate binds to and blocks dopamine transporters and norepinephrine transporters..

While both amphetamine and methylphenidate are dopaminergic, it should be noted that their methods of action are somewhat distinct. Specifically, methylphenidate is a dopamine reuptake inhibitor while amphetamine is both a releasing agent and reuptake inhibitor of dopamine and norepinephrine. Each of these drugs have a corresponding effect on norepinephrine which are weaker than their effects on dopamine. Methylphenidate’s mechanism of action at dopamine-norepinephrine release is still debated, but is fundamentally different from most other phenethylamine derivatives as methylphenidate is thought to increase general firing rate, whereas amphetamine reduces firing rate and reverses the flow of the monoamines via TAAR1 activation...


Threshold 5 mg
Light 10 – 20 mg
Common 20 – 40 mg
Strong 40 – 60 mg
Heavy 60 mg +
Total 4 – 6 hours
Onset 20 – 60 minutes
Come up 20 – 60 minutes
Peak 1.5 – 2.5 hours
Offset 1 – 2 hours
After effects 2 – 6 hours



Cognitive effects

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Additional information


30g, 50g, 100g, 500g, 1kg


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