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Hexedrone is a stimulant of the substituted cathinone class. Through analysis of the Structure-Activity Relationships in similar cathinones such as MDPV, Hexedrone is believed to be a norepinephrine–dopamine reuptake inhibitor. .
Molar mass219.33 g/mol
AppearanceWhite crystalline solid
PubChem CID132493708
Chemical formulaC13H18NO
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SKU: 54344 Category: Tags: ,

Description

Hexedrone is a novel synthetic stimulant of the cathinone class. It has been speculated to act as a norepinephrinedopaminereuptake-inhibitor (NDRI). and a stimulant of the substituted cathinone class. Through analysis of the Structure-Activity Relationships in similar cathinones such as MDPV, Hexedrone is believed to be a norepinephrine–dopamine reuptake inhibitor.

Subjective effects include stimulationdisinhibitionthought acceleration and euphoria.

Little is known about toxicity, addiction, and abuse potential of hexedrone. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with caution.

Chemistry

Hexedrone is a cathinone, which is closely related to amphetamines, but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R2 position, a n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that’s attached to the amine (R4), thus forming N-Methyl.

Pharmacology

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other cathinones such as pentedrone and others. Hexedrone most likely acts as both a dopamine and norepinephrine reuptake inhibitor. This allows dopamine and norepinephrine to build up within the brain, resulting in stimulating and euphoric effects.

The decreased potency, compared to both pentedrone as well as ethyl-hexedrone can be easily explained. Compared to pentedrone, there is a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.

Dosage
Threshold 30 mg
Light 50 – 70 mg
Common 70 – 100 mg
Strong 100 – 125 mg
Heavy 100 mg +
Duration
Total 1 – 4 hours
Onset 15 – 30 minutes
After effects 1 – 12 hours
DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
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Additional information

Weight

18g, 25g, 50g, 200g, 500g, 1kg

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