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4-HO-MiPT is a synthetic substituted aromatic compound and a lesser-known psychedelic tryptamine. It is thought to be a serotonergic psychedelic, similar to magic mushrooms, LSD and mescaline. .
Molar mass232.32 g/mol
ChemSpider ID8258221
ChEMBL Id171419
Other names4-hydroxy-N-methyl-N-isopropyltryptamine
PubChem CID10082683
FormulaC14H20N2O
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SKU: 54309 Categories: , Tags: , ,

Description

4-Hydroxy-N-methyl-N-isopropyltryptamine (also known as 4-HO-MiPT, and Miprocin) is a novel psychedelic substance of the tryptamine class that produces psilocybin-like psychedelic effects when administered. It is part of a series of psychedelic substituted tryptamines such as 4-AcO-DMT4-HO-MET4-HO-DiPT that are considered to produce variations of the core psychedelic effects typified by psilocin.

This substance is relatively uncommon and has only a short history of human use. Alexander Shulgin evaluated its activity in humans in 1979, describing a trial of 12mg as a richly insightful and highly erotic experience..  A description of 4-HO-MiPT is included in Shulgin’s 1997 book TiHKAL. .Shulgin’s trials and other anecdotal reports suggest that 4-HO-MiPT is similar in activity to psilocin, the active component in psilocybin mushrooms.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MiPT in humans. As with psilocin, there have been no reported deaths from 4-HO-MiPT use despite the existence of reports of people taking doses which far exceeds the active dose. This suggests that it is well-tolerated physiologically.[.

Today, 4-HO-MiPT is either used recreationally or as an entheogenic substance and is typically distributed as a grey-area research chemical by online vendors.

 

Chemistry

Generic structure of a tryptamine molecule.

4-HO-MiPT or 4-hydroxy-N-methyl-N-isopropyltryptamine is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-MiPT is substituted at R4 of its indole heterocycle with a hydroxyl (HO) functional group OH-. It also contains a methyl group and an isopropyl chain bound to the terminal amine RN of its tryptamine backbone (MiPT). 4-HO-MiPT is the N-substituted isopropyl homologue of 4-HO-DMT (Psilocin)..

Pharmacology

Further information: Serotonergic psychedelic

4-HO-MiPT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

 

Dosage
Threshold 5 – 10 mg
Light 10 – 15 mg
Common 15 – 25 mg
Strong 25 – 35 mg
Heavy 35 mg +
Duration
Total 4 – 6 hours
Onset 15 – 45 minutes
Come up 20 – 60 minutes
Peak 1.5 – 2.5 hours
Offset 1 – 2 hours
After effects 2 – 12 hours
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