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3-Fluoroethamphetamine is a stimulant drug of the amphetamine class which acts as a releasing agent of the monoamine neurotransmitters norepinephrine, dopamine and serotonin..
PubChem CID57458869
FormulaC11H16FN
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Description

3-Fluoroethamphetamine (also known as 3-FEA) is a novel ring-substituted amphetamine compound that produces a mixture of entactogenic and stimulant effects when administered. 3-FEA is structurally related to a series of designer fluorinated substituted amphetamines that originally included compounds such as 2-FA2-FMA3-FA4-FMA4-FA..

Like its parent compound 3-FA, the pharmacological, toxicological, and subjective effects of 3-FEA in humans have yet to be mapped out in detail. Anecdotal reports have characterised 3-FEA as a moderately potent serotonin-dominant triple monoaminereleaser that produces a mixture of entactogenic and mild stimulating effects..

3-FEA has an extremely short history of human recreational use and has not been documented being sold on the streets. It has recently been made available for sale on the grey market as a research chemical by online vendors.. Due to its potent psychostimulant effects, likely habit-forming properties, and unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if using this substance.

Chemistry

Generic structure of an amphetamine molecule

3-FEA, or 3-fluoroethamphetamine, is a synthetic molecule of the amphetamine chemical class. Molecules of the amphetamine class contain a phenethylamine core comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain substituted with a methyl group at Rα (i.e. amphetamines are alpha-methylated phenethylamines).

3-FEA is the 3-position fluorinated analog of ethylamphetamine (also known as ethamphetamine). It is also an analog of fenfluramine with the 3-trifluoromethyl group replaced with a 3-fluoro substituent..

 

Pharmacology

Although 3-FEA has not been formally studied on the same level as traditional amphetamines, it is currently assumed that like other substituted amphetamines with substitutions at similar positions, it most likely acts primarily as a triple reuptake inhibitorand/or releaser of the monoamine neurotransmitters serotonindopamine, and norepinephrine...

It has been demonstrated that compared to the unsubstituted ethylamphetamine, 3-fluoroethamphetamine is a weaker releaser of dopamine, but a stronger releaser of both serotonin and norepinephrine, producing the strongest reinforcing effects in animal studies out of a range of 3-substituted amphetamine derivatives tested, despite not being the most potent dopamine releaser..

This indicates that 3-FEA effectively increases the levels of all the three major monoamine neurotransmitters dopamine, norepinephrine, and serotonin in the brain by acting as a releasing agent of said neurotransmitters and/or by binding to and partially blocking the transporter proteins that normally clear those molecules from the synaptic cleft after they have fulfilled their function of conducting a neural impulse. This transporter blockade allows these molecules to accumulate within core synaptic regions of the brain to extra-endogenous levels, resulting in a combination of relaxingstimulatingdisinhibiting and euphoric effects associated with entactogenic substituted amphetamines such as MDMA or 4-FA..

Dosage
Threshold 15 – 20 mg
Light 20 – 35 mg
Common 35 – 70 mg
Strong 70 – 90 mg
Heavy 90 mg +
Duration
Total 4 – 6 hours
Onset 20 – 60 minutes
Come up 30 – 60 minutes
Peak 1.5 – 2.5 hours
Offset 2 – 3 hours
After effects 6 – 12 hours
Insufflated
Dosage
Threshold 15 – 20 mg
Light 20 – 35 mg
Common 35 – 60 mg
Strong 50 – 60 mg
Heavy 60 mg +
Duration
Total 1 – 2 hours
Onset 5 – 15 minutes
Come up 5 – 10 minutes
Peak 30 – 60 minutes
Offset 30 – 60 minutes
After effects 1 – 3 hours
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